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KMID : 1098420040120040315
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Korean Journal of Medicinal Crop Science
2004 Volume.12 No. 4 p.315 ~ p.320
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Effects of Orostachys japonicus A. Berger on the Immune System
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Kwon Jin
Han Kwang-Soo
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Abstract
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The purpose of this research was to investigate the effect of Orostachys japonicus A. Berger (OJB) on the immune system. Administration of OJB (500 mg/kg) enhanced viability of splenocytes and thymocytes in BALB/c mice, and also OJB increased of splenic T lymphocytes, significantly, increased CD4 positive T_H cells and CD8 positive Tc cells. OJB markedly, enhanced the production of {gamma}-interferon in mice serum. OJB accelerated the apoptosis of L1210 and U937 leukemia cells and increased the expression of apoptosis-related ICE, c-myc, p53 gene. These results suggest that OJB have an immuno-regulatory and anti-cancer activity.
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KEYWORD
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immune system, {gamma}-interferon, apoptosis, anti-cancer activity
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